Table 1.
Portal Vein and Mesenteric Lymph Absorption and Tissue Distribution of Icosabutate
| A | |||||||
|---|---|---|---|---|---|---|---|
| Portal Vein Plasma (Blood Flow Rate: 522 mL/h)* | Mesenteric Lymph (Lymph Flow Rate: 0.5 mL/h) | Portal Vein/Lymph Ratio | |||||
| Cmax (µg/mL) | Tmax (h) | AUC0‐24h (µgˑh/mL) | Cmax (µg/mL) | Tmax (h) | AUC0‐24h (µgˑh/mL) | ||
| Icosabutate in corn oil | 17.6 | 2 | 106 | 8.4 | 3 | 46 | 1,200:1 |
| B | |||||||
|---|---|---|---|---|---|---|---|
| Activity (µg/g tissue) | |||||||
| 1 Hour | 2 Hours | 4 Hours | 8 Hours | 1 Day | 3 Days | ||
| Liver | 77.7 | 134.0 | 174.0 | 145.0 | 25.5 | 2.7 | |
| Kidney cortex | 34.0 | 70.6 | 92.8 | 38.5 | 9.8 | 1.5 | |
| Kidney medulla | 47.3 | 148.0 | 102.0 | 76.6 | 34.5 | 0.5 | |
| Muscle | 3.6 | 5.2 | 10 | 4.8 | 1.2 | BLQ | |
| Subcutaneous fat | 9.0 | 14.6 | 25.3 | 15.4 | 7.1 | 4.0 | |
| Blood | 24.6 | 36.2 | 60.9 | 28.1 | 2.6 | BLQ | |
*
Assuming a volume ratio of plasma:blood of 1:2.
Abbreviations: BLQ, below the limit of quantification; h, hours.