Figure 4.

N‐acetyl‐cysteine (NAC) treatment reduces 47S levels and 35S incorporation in multiple myeloma cells lines overexpressing ACA11. A, 45S pre‐rRNA levels in MM1.S (B) 47S pre‐rRNA levels in MM1.S and (C) H929 cells analyzed by real‐time quantitative reverse transcription PCR in response to NAC (1.0 mmol/L) treatment for 24 h. D, Amount of protein synthesized at basal condition and after treatment with NAC for 24 hours in MM1.S and (E) H929 cells were measured by analyzing the amount of 35S incorporation over a 4‐h time period. *P < 0.05