Table 1.
Echocardiographic and anatomical analysis as a function of transverse aortic constriction (TAC). Statistical analysis was performed with a two‐way ANOVA analysis
| Time post surgery | 4 wk | |||
|---|---|---|---|---|
| Genotype | HMGB1Flox Sham | HMGB1ΔMac Sham | HMGB1Flox + TAC | HMGB1ΔMac + TAC |
| Echocardiographic parameters | ||||
| LVEDD (mm) | 3.443 ± 0.12 | 3.435 ± 0.11 | 4.018 ± 0.15** | 3.846 ± 0.12** |
| LVESD (mm) | 1.955 ± 0.09 | 1.98 ± 0.12 | 2.604 ± 0.22* | 2.39 ± 0.16* |
| FS (%) | 43.25 ± 1.93 | 42.25 ± 1.79 | 36.25 ± 3.29 | 38.36 ± 2.37 |
| Anatomical parameters | ||||
| BW (g) | 31.94 ± 0.54 | 30.49 ± 1.25 | 27.29 ± 0.90** | 28.73 ± 0.69** |
| Heart weight (mg) | 144.3 ± 7.14 | 152 ± 3.51 | 169.5 ± 11.21* | 174.3 ± 6.38* |
| HW/TL (mg/mm) | 78.27 ± 3.81 | 82.51 ± 1.70 | 97.8 ± 6.22** | 98.6 ± 3.64** |
Data are expressed as means ± SEM. n = 4 in HMGB1Flox/sham group; n = 4 in HMGB1ΔMac/sham group; n = 8 in HMGB1Flox/TAC group; n = 13 in HMGB1ΔMac/TAC group.
BW, body weight; FS, fractional shortening; HMGB1, high mobility group B1; HW/TL, heart weight to tíbia length ratio; LVEDD, left ventricular end‐diastolic dimension; LVESD, left ventricular end‐systolic dimension; TAC, transverse aortic constriction.
*
P < 0.05.
**
P < 0.01 vs sham/TAC.