Table 3.
Significantly enriched gene ontology categories in the livers of L1‐Tg mice as compared with WT mice
| Categories | Number of genes | Enrichment factor | P‐value | |
|---|---|---|---|---|
| Up‐regulated | Down‐regulated | |||
| Defense response to virus | 18 | 1 | 7.03 | <0.001 |
| Response to virus | 16 | 1 | 12.8 | <0.001 |
| Innate immune response | 17 | 0 | 4.17 | <0.001 |
| Double‐stranded RNA binding | 9 | 0 | 7.66 | <0.001 |
| Anchored to membrane | 9 | 0 | 3.79 | 0.001 |
| Immune response | 9 | 0 | 2.75 | 0.006 |
| Cellular response to interferon‐beta | 7 | 0 | 13.3 | <0.001 |
| Negative regulation of viral genome replication | 6 | 0 | 11.4 | <0.001 |
| 2′‐5′oligoadenylate synthetase activity | 5 | 0 | 40.0 | <0.001 |
| Cellular response to lipopolysaccharide | 5 | 0 | 4.25 | 0.006 |
| Glycoprotein binding | 2 | 3 | 4.28 | 0.007 |
Enrichment factors for each GO term were defined as (nf/n)/(Nf/N), where nf is the number of flagged (differentially expressed) genes within a category, Nf is the total number of genes within the same category, n is the number of flagged genes in the entire microarray, and N is the total number of genes on the microarray.