Table 1.
Modeling human proteinopathies in genetically tractable model organisms
| Misfolding protein | Proteinopathy | Model organism | References |
|---|---|---|---|
| α-Synuclein | Parkinson's disease | Saccharomyces cerevisiae | Outeiro and Lindquist 2003; Willingham et al. 2003; Dixon et al. 2005; Zabrocki et al. 2005; Sharma et al. 2006 |
| Drosophila melanogaster | Feany and Bender 2000; Auluck et al. 2002 | ||
| Caenorhabditis elegans | Lakso et al. 2003; Cao et al. 2005; Kuwahara et al. 2006; Hamamichi et al. 2008; van Ham et al. 2008 | ||
| β-Amyloid | Alzheimer's disease | S. cerevisiae | Bagriantsev and Liebman 2006; Caine et al. 2007; von der Haar et al. 2007; Treusch et al. 2011; D'Angelo et al. 2013 |
| D. melanogaster | Finelli et al. 2004; Iijima et al. 2004; Crowther et al. 2005; Iijima et al. 2008 | ||
| C. elegans | Link 1995; Link et al. 2003 | ||
| tau | Alzheimer's disease, FTDP-17 | S. cerevisiae | Vandebroek et al. 2005 |
| D. melanogaster | Williams et al. 2000; Wittmann et al. 2001; Jackson et al. 2002; Blard et al. 2007 | ||
| C. elegans | Kraemer et al. 2003; Miyasaka et al. 2005; Brandt et al. 2009 | ||
| huntingtin | Huntington's disease | S. cerevisiae | Krobitsch and Lindquist 2000; Muchowski et al. 2000; Duennwald et al. 2006a,b; Solans et al. 2006; Kayatekin et al. 2014 |
| D. melanogaster | Jackson et al. 1998 | ||
| C. elegans | Faber et al. 1999; Parker et al. 2001 | ||
| Polyglutamine (polyQ) | Polyglutamine-expansion disorders (e.g., spinocerebellar ataxia type 1, type 3) | S. cerevisiae | Fernandez-Funez et al. 2000; Meriin et al. 2002, 2003 |
| D. melanogaster | Warrick et al. 1998; Kazemi-Esfarjani and Benzer 2000; Marsh et al. 2000 | ||
| C. elegans | Satyal et al. 2000; Brignull et al. 2006 | ||
| TDP-43 | Amyotrophic lateral sclerosis | S. cerevisiae | Johnson et al. 2008; Elden et al. 2010; Kim et al. 2014 |
| D. melanogaster | Kim et al. 2014 | ||
| FUS | Amyotrophic lateral sclerosis | S. cerevisiae | Fushimi et al. 2011; Ju et al. 2011; Kryndushkin et al. 2011; Sun et al. 2011 |
| SOD1 | Amyotrophic lateral sclerosis | S. cerevisiae | Rabizadeh et al. 1995; Ticozzi et al. 2011 |
| D. melanogaster | Watson et al. 2008; Bahadorani et al. 2013; Gallart-Palau et al. 2016; Şahin et al. 2017 | ||
| C. elegans | Oeda et al. 2001; Gidalevitz et al. 2009; Wang et al. 2009 | ||
| Islet amyloid polypeptide (IAPP) | Type 2 diabetes | S. cerevisiae | Kayatekin et al. 2018 |