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. 2020 Jan 27;10:3087. doi: 10.3389/fimmu.2019.03087

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Copyright © 2020 Quero, Tiaden, Hanser, Roux, Laski, Hall and Kyburz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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JAK3 as top downregulated gene of unstimulated M2-macrophages transfected with miR-221-3p. (A) Volcano plot showing the differentially expressed genes between cells transfected with miR-221-3p mimic and control cells in untreated conditions. Significant genes are colored in red (up-regulated) and blue (down-regulated). (B) Significantly enriched KEGG pathways among differentially expressed genes upon transfection in untreated conditions after gene set enrichment analysis. The absolute log2 fold-change (x-axis) is shown relative to the significance (y-axis). Significant pathways are colored in yellow (up-regulated pathway) and blue (down-regulated pathway). The dot size indicates the number of genes annotated in each pathway.