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JAK3 activity was inhibited in generated M2-macrophages from blood of HD or RA patients using two selective JAK inhibitors FM-381 and Tofacitinib. Cells were treated 1 h before LPS stimulation with 1 μM JAK inhibitor or DMSO control. Cytokine and chemokine secretion were measured by ELISA after stimulation with LPS for 24 h. Values are expressed as mean ± S.D. N = 3–8, *p < 0.05.
