Table 1.
Demographics and outcomes of infants exposed to sildenafil
| <32 wk N = 783 |
≥32 wk N = 552 |
|
|---|---|---|
| Male | 439 (56) | 308 (56) |
| Antenatal steroids | 632 (81) | 71 (13) |
| Median gestational age, wk (IQR) | 25 (24, 27) | 38 (36, 39) |
| Median birth weight, g (IQR) | 655 (545, 800) | 3,015 (2,474, 3,501) |
| Diagnoses | ||
| Pulmonary hypertension | 631 (81) | 488 (88) |
| Meconium aspiration syndrome | 0 | 76 (14) |
| Congenital diaphragmatic hernia | 5 (<1) | 94 (17) |
| Congenital heart disease | 18(2) | 80 (14) |
| Bronchopulmonary dysplasiaa | 666 (95) | 248 (55) |
| Interventions | ||
| Mechanical ventilation | 760 (97) | 484 (88) |
| Inhaled nitric oxide | 279 (36) | 197 (36) |
| Surfactant | 265 (34) | 84 (15) |
| Inotropes | 313 (40) | 287 (52) |
| Outcome | ||
| Deathb | 135 (26) | 74 (19) |
| Severe retinopathy of prematurity | 148 (19) | 0 |
Abbreviation: IQR, interquartile range.
Note: Data are n (%), unless otherwise indicated.
a
One hundred and seventy-six infants were transferred to other acute care facilities before bronchopulmonary dysplasia outcome could be determined.
b
Four hundred ten infants were transferred to other acute care facilities before mortality outcomes could be determined.