Table 1.
MAO A and B Inhibition Percentages Measured at One-Point Screening of Anilides (Screening Concentration 1 µm)
| n | % Inhibition at 1 µm | n | % Inhibition at 1 µm | ||
|---|---|---|---|---|---|
| MAO A | MAO B | MAO A | MAO B | ||
| 1 | 12±8 | 5±3 | 15 | 9±3 | 7±5 |
| 2 | 11±5 | 2±4 | 16 | 20±12 | 14±10 |
| 3 | 29±3 | 27±3 | 17 | 10±5 | 69±28 |
| 4 | 24±20 | 29±3 | 18 | 18±5 | 24±9 |
| 5 | 1±2 | −2±3 | 19 | 13±2 | 11±7 |
| 6 | 16±7 | 7±5 | 20 | 72±2 | 61±4 |
| 7 | 82±2 | 46±4 | 21 | 13±1 | 10±7 |
| 8 | 10±4 | 1±3 | 22 | 2±1 | 14±3 |
| 9 | 14±7 | 14±5 | 23 | 23±3 | 25±4 |
| 10 | 28±8 | 25±3 | 24 | 27±4 | 48±5 |
| 11 | 48±3 | 85±1 | 25 | 25±2 | 11±4 |
| 12 | 28±8 | 5±3 | 26 | 11±2 | 2±3 |
| 13 | 50±4 | 32±10 | 27 | 20±6 | 44±23 |
| 14 | 49±5 | 18±11 | 28 | 8±4 | 5±2 |
| 29 | 15±1 | 87±5 | 41 | 8±4 | 85±3 |
| 30 | 7±3 | 38±7 | 42 | 5±3 | 30±5 |
| 31 | 82±1 | 104±2 | 43 | 4±8 | 0±5 |
| 32 | 45±5 | 66±5 | 44 | 34±3 | 6±2 |
| 33 | 74±2 | 96±2 | 45 | 13±2 | 36±4 |
| 34 | 71±5 | 96±1 | 46 | 13±3 | 68±2 |
| 35 | 8±1 | 5±10 | 47 | 35±3 | 36±4 |
| 36 | 6±4 | 84±12 | 48 | 5±5 | 1±2 |
| 37 | 13±4 | 30±10 | 49 | 3±3 | 13±6 |
| 38 | 9±2 | −2±2 | 50 | 6±5 | 62±2 |
| 39 | 20±8 | 91±1 | 51 | 3±4 | 34±2 |
| 40 | 8±4 | 6±2 | 52 | 19±4 | 80±4 |
| 53 | 38±6 | 87±1 | 60 | −12±18 | 67±2 |
| 54 | 7±9 | 24±26 | 61 | −3±5 | 72±2 |
| 55 | 44±4 | 91±2 | 62 | −2±20 | 48±5 |
| 56 | 1±2 | 47±5 | 63 | −3±19 | 44±23 |
| 57 | 9±9 | 62±7 | 64 | 84±2 | 80±4 |
| 58 | 11±7 | 58±1 | 65 | 52±10 | 92±4 |
| 59 | −4±10 | 28±2 | 66 | 11±8 | 40±31 |
Notes: aData represent mean values ± standard deviation of at least two independent experiments each performed in duplicates (global fit). Percentage values were calculated relative to control (set to 100% remained activity). Bold values represent inhibition rates >90 % MAO B and highest MAO A inhibitions.