Table 2.
MAO A and B Inhibition Activities of the Most Potent Compounds Expressed as IC50 Values Within the 95%CI
| No. | IC50 [nM] [95%CI] (N)a | ||
|---|---|---|---|
| hMAO B | hMAO A | MAO SI c | |
| 7 (ST-2023) | 1052 [759; 1459] (3) | 126 [101; 158] (4) | 0.1 |
| 31 | 92.3 [70.3; 121] (3) | >1000b | >10.8 |
| 33 | 128 [54.0; 305] (3) | >1000b | >7.8 |
| 34 | 139 [64.7; 300] (3) | >1000b | >7.2 |
| 39 | >1000b | >5000b | |
| 55 (ST-2043) | 55.5 [31.9; 96.7] (5) | 289 [193; 433] (5) | 5.2 |
| 65 | 123 [87.6; 172] (5) | 293 [203; 424] (3) | 2.4 |
| Safinamided | 53 [20, 141] (4) | >50000 (4) | >940 |
Notes: aData represent mean values within the 95%CI of multiple independent experiments (n) each performed in duplicates. bCompounds did not reach bottom plateau at highest tested concentrations; Data are estimates extrapolated with bottom was set to zero. cSelectivity index (SI) = IC50 MAO A/IC50 MAO B. dValues taken from Affini et al.21