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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Brain Res. 2019 Nov 29;1728:146573. doi: 10.1016/j.brainres.2019.146573

Figure 2.

Figure 2

The sEH inhibitor TPPU does not induce significant change in the open field behavior of the healthy animals unlike the positive controls. A) The open field scores were assessed 60 minutes post treatment on alternate days and, as repeated daily dosing progressed, morphine first depressed locomotion (Day 1, * p ≤ 0.001) and then displayed typical hyperlocomotion (Day 3–6) which also showed tolerance development by Day 9. B) Pregabalin showed significant increases (* p ≤ 0.001) in pre to post open field scores without tolerance (calculated as 60 min post score/pretreatment score *100) while TPPU showed no change from vehicle. C) With continued treatment pregabalin negatively impacted the pretreatment daily baseline scores depicted here and rats responded to the drug administration with typical disinhibition (increased motility) resulting in the large increases in the calculated scores in Fig 2B.