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TPPU does not alter the gaiting of healthy rats while pregabalin does. Compounds were assessed to affect gaiting as an outcome of their CNS effects and changes in motor skill. Measurement of gait demonstrated A) stride length and B) stride width were altered in naïve rats 1.5 hr post oral gavage of pregabalin but not TPPU. The pregabalin dose resulted in significant differences (p ≤ 0.001) while TPPU showed no change from vehicle.
