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. 2020 Feb;6(1):a004531. doi: 10.1101/mcs.a004531

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© 2020 Wilk et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial License, which permits reuse and redistribution, except for commercial purposes, provided that the original author and source are credited.

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Figure 2. — Wisconsin chest X-ray scores (Koscik et al. 2000) in the three brothers as compared to published data (Farrell et al. 2003) from the Wisconsin randomized clinical trial (RCT) of the newborn screening (NBS) cohort in which a thoracic radiologist and pediatric pulmonologist rated chest radiographs independently, with their scores being averaged. The data obtained on three brothers are shown as A (eldest), B (middle), and C (youngest) and demonstrated that the youngest had lower and therefore milder lung disease than his brothers throughout childhood. In the case of the eldest brother labeled A, the scores assigned by the same pediatric pulmonologist were adjusted to conform with the averaging method. The gray shaded area labeled D represents the mean ± 95% confidence interval for the entire RCT cohort. (CXR) Chest X-ray.