Figure 7. Model for the regulation of the chromosomal assembly of ASY1.

In early prophase I, ASY1 is expressed and imported into nucleus, facilitated by PCH2. Concomitantly, CDKA;1 becomes enriched in the nucleus, localizes on chromosomes, and phosphorylates ASY1. The phosphorylation enhances the binding affinity of ASY1 to ASY3 and the self‐assembly and thus, in turn, antagonizes the releasing force of PCH2. At the same time, high CDKA;1 activity in the nucleus may block other axis disassembling factors that will be activated later in synapsed regions where CDKA;1 is not present.