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. 2020 Jan 10;39(3):e102525. doi: 10.15252/embj.2019102525

Figure 7. FA metabolism and mitochondrial dynamics are associated with melanoma aggressiveness.

Figure 7

  1. TCGA data were analyzed to reveal the effect of high mRNA levels of key FAO enzymes on the overall survival of patients with melanoma. Statistical significance of survival was evaluated with a Log‐rank (Mantel‐Cox) test (n = 449, 450, and 459 for HADHA, HADHB, and ECHS1, respectively).
  2. BODIPY staining of neutral lipid stores in the indicated melanoma cell lines, which present increasing degrees of aggressiveness (from left to right). DAPI was used to counterstain nuclei. Scale bar: 20 μm.
  3. FAO in the indicated melanoma cell lines was measured. Bars and error bars represent means ± SEM (n = 5); statistically significant by one‐way ANOVA with post hoc Tukey's test, ***P < 0.001. If not indicated, non‐significant.
  4. TCGA data were analyzed to reveal the effect of high mRNA levels of key actors in mitochondrial dynamics on the overall survival of patients with melanoma. Statistical significance of survival was evaluated with a Log‐rank (Mantel‐Cox) test (n = 459).