Table 3.
Associations of postdiagnosis waist-to-hip ratio and mortality among 621 breast cancer survivors in the Health, Eating, Activity, and Lifestyle study
| Waist-to-hip ratio | Multivariate hazard ratios (95 % CI) death from any cause |
Multivariate hazard ratios (95 % CI) breast cancer death |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Q1 (0.64–0.77) | Q2 (0.78–0.83) | Q3 (0.83–0.88) | Q4 (0.88–1.04) | p trend | Q1 (0.64–0.77) | Q2 (0.78–0.83) | Q3 (0.83–0.88) | Q4 (0.88–1.04) | p trend | |
| N | 155 | 155 | 156 | 155 | 155 | 155 | 156 | 155 | ||
| Deaths | 17 | 23 | 29 | 38 | 5 | 13 | 14 | 16 | ||
| Base modela | 1.00 | 1.38 (0.71, 2.66) | 1.93 (1.00, 3.7) | 2.04 (1.06, 3.94) | 0.026 | 1.00 | 3.16 (1.09, 9.17) | 3.37 (1.14, 10.02) | 4.31 (1.41, 13.17) | 0.018 |
| Full modelb | 1.00 | 1.53 (0.79, 2.95) | 2.08 (1.07, 4.01) | 2.10 (1.08, 4.05) | 0.028 | 1.00 | 3.32 (1.14, 9.62) | 3.38 (1.14, 10.02) | 4.02 (1.31, 12.31) | 0.029 |
| Full model + C-peptide quartilesc | 1.00 | 1.76 (0.87, 3.57) | 2.67 (1.30, 5.48) | 2.47 (1.20, 5.09) | 0.017 | 1.00 | 3.27 (1.09, 9.82) | 3.59 (1.14, 11.23) | 4.19 (1.27, 13.90) | 0.032 |
| Full model + HOMA quartilesd | 1.00 | 1.66 (0.82, 3.35) | 2.33 (1.13, 4.82) | 2.09 (1.02, 4.29) | 0.062 | 1.00 | 3.32 (1.10, 10.04) | 3.19 (1.00, 10.16) | 3.78 (1.12, 12.68) | 0.061 |
| Full model + IGF1-BP3 ratio quartilese | 1.00 | 1.65 (0.83, 3.31) | 2.44 (1.21, 4.92) | 2.40 (1.19, 4.84) | 0.014 | 1.00 | 3.35 (1.12, 10.00) | 3.61 (1.18, 11.04) | 4.28 (1.33, 13.84) | 0.024 |
| Full model + C-reactive protein quartilesf | 1.00 | 1.60 (0.80, 3.20) | 2.17 (1.07, 4.40) | 1.98 (0.97, 4.04) | 0.075 | 1.00 | 3.10 (1.04, 9.27) | 3.19 (1.02, 9.93) | 3.60 (1.11, 11.68) | 0.06 |
| Full model + adiponectin quartilesg | 1.00 | 1.66 (0.83, 3.34) | 2.42 (1.20, 4.90) | 2.17 (1.06, 4.44) | 0.041 | 1.00 | 3.16 (1.07, 9.35) | 3.26 (1.06, 10.07) | 3.72 (1.15, 12.05) | 0.049 |
a
Adjusted for measured BMI (<18.5, 18.5–24.9, 25–29.9, 30–34.9, 35+); treatment(surgery, +radiation, +chemo, +radiation and chemo); number of activity-limiting comorbidities; race/ethnicity (non-Hispanic white, Hispanic, African-American, other); Healthy Eating Index 2005 score quartiles
b
Base model + adjustment for postdiagnosis recreational physical activity (0, 0.1–8.9, 9+ MET-h/wk)
c
Among 562 women
d
Among 546 women
e
Among 561 women
f
Among 556 women
g
Among 560 women