Figure 15a.

Alzheimer disease. (a, b) Coronal (a) and sagittal (b) T1-weighted MR images in a patient with suspected Alzheimer disease show mild-to-moderate generalized volume loss. (c, d) Axial (c) and sagittal (d) ¹⁸F-FDG PET images show markedly decreased activity in the bilateral frontal lobes and precunei. Image insets show a coronal section through the middle of the brain in this particular case to aid in lateralization. (e) Axial ¹⁸F-florbetaben image shows diffuse cortical uptake, which is a grossly abnormal finding, confirming amyloid deposition. Corroborative imaging findings are supportive of the clinical diagnosis of Alzheimer disease.