Table 1.

Genes and variants associated with susceptibility for acute pancreatitis compared with previously published meta‐analyses

		Present meta‐analysis					Previous meta‐analyses
Gene	Variant	No. of cases	No. of controls	No. of studies	Outcome	Credibility*	Reference	No. of cases	No. of controls	No. of studies	Outcome†
SPINK1	rs17107315	1493	2595	9	+	A	Joergensen et al.21	1135	2822	8	+
IL1B	rs1143634	1301	1171	6	+	C	Yin et al.22	519	388	3	+
CXCL8 (IL8)	rs4073	1770	1990	9	+	C	Yin et al.22	503	758	5	+
ACE	rs4646994	770	4878	4	−		Fang et al.23	245	1455	3	+
CCL2	rs1024611	470	562	4	−		Fang et al.24	567	562	4	+
CD14	rs2569190	1328	1195	6	−		Yuan and Wang25	1211	932	5	−
IL10	rs1800896	1738	1691	8	−		Yin et al.22	339	243	2	−
TLR4	rs4986790	994	794	4	−		Zhou et al.26	1255	998	6	−
TNF	rs1800629	1335	1076	6	−		Yin et al.27	1006	782	6	−

^*Assessed by Venice criteria, based on sample size, heterogeneity among studies, and risk of bias.

^†Reported by original author.

+, positive association; −, no association.