Table 5.

Genes and variants associated with disease severity or complications of acute pancreatitis that were not replicated in another study^*

Gene	Variant	Reference	Outcome	Incidence (%)	No. of cases	No. of controls	Risk allele
Severity
CD14	rs5744455	Masamune et al.34	SAP	31	107	238	C
TLR3	rs3775291	Matas‐Cobos et al.48	SAP	13	36	233	C
TLR4	G11367C	Zhang et al.49	SAP	33	150	300	C
TLR6	rs7543795	Matas‐Cobos et al.48	SAP	13	36	233	A
NFKBIA	rs696	Zhang et al.49	SAP	33	150	300	T
PLA2G7	rs16874954	Ma et al.50	SAP	51	486	46	A
PLA2G7	rs1805017	Ma et al.50	SAP	51	48	46	A
PPARG	rs1801282	Zhang et al.51	SAP	33	150	300	G
SERPINE1	rs1799889	Tukiainen et al.52	SAP	33	150	300	5G
Pancreatic necrosis
HMOX1	S/L	Gulla et al.53	Pancreatic necrosis	50	63	64	L
Infectious complications
CD14	rs5744455	Masamune et al.34	Infected necrosis	9	32	314	C
TLR4	rs4986790	Gao et al.54	Infected necrosis	24	30	95	G
DEFB1	rs11362	Tiszlavicz et al.55	Infected necrosis	23	29	95	A
DEFB1	rs1799946	Tiszlavicz et al.55	Infected necrosis	23	29	95	C
IL10	rs1800896	Zhang et al.56	Septic shock	30	33	76	G
REN	rs5707	Skipworth et al.57	Infected necrosis	14	52	317	G
Systemic complications
TNF	rs1799964	Bishehsari et al.58	MODS	11	23	188	C
TNF	rs1800630	Bishehsari et al.58	MODS	11	23	188	A
TNF	rs361525	de‐Madaria et al.59	Systemic complications	11	9	75	A
TNFAIP3	rs5029924	Liu et al.60	SIRS	35	47	88	T
PLA2G7	rs16874954	Ma et al.50	MODS	6	6	88	A
Mortality
REN	rs5707	Skipworth et al 57	Mortality	7	36	477	C
Surgery
TLR2	Microsatellite	Takagi et al.61	Surgery	15	30	172	S

^*Reported by original author.

SAP, severe acute pancreatitis; MODS, multiple organ dysfunction syndrome; SIRS, systemic inflammatory response syndrome.