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. 2019 Oct;60(13):4257–4269. doi: 10.1167/iovs.19-27574

Figure 4.

Figure 4

GCIPL thickness reduction patterns. Using different cutoff settings, the areas of focal thickness alterations were visualized in MSON (A) and MSFE (B) in comparison to HC. A horseshoe-like thickness reduction pattern was found in MSON (A). The schematic diagram shows the definition of the horseshoe shape of the thickness reduction, named as the “U Zone.” The horseshoe-like thickness reduction was defined as the “U Zone” with a portion of an elliptic annulus (dimensions: 1.45 and 3.5 mm for the inner and outer vertical diameters, respectively, and 1.8 and 4.9 mm for the inner and outer horizontal diameters, respectively) around the fovea. In contrast, MSFE showed an island pattern located on the nasal side (B). GCIPL thickness (C) and proportional thicknesses (D) of the U Zone exhibited significant reductions in MSON compared with MSFE and HC. Similar horseshoe-like thickness reduction patterns were also evident in the proportional thickness maps, which were calculated as (MSON-HC)/HC and (MSFE-HC)/HC.