Figure 1.

Vaccine virus shed in nasal washes (NWs) in vaccinees. Titers from individual participants (closed circles and open diamonds) and median titers (solid line) of vaccine virus detected in NWs collected from vaccinees during study visits (indicated study day ±1 day) after inoculation on day 0, determined by immunoplaque assay ([A] log₁₀ plaque-forming units [PFU] per mL) and reverse-transcription quantitative polymerase chain reaction (RT-qPCR) ([B] log₁₀ copies per mL). Peak titers for each participant are indicated by open diamonds; nonpeak titers are indicated by closed circles. Lower limits of detection indicated by dashed lines were 0.5 log₁₀ PFU/mL and 1.7 log₁₀ copies/mL for immunoplaque assay and RT-qPCR, respectively.