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. 2020 Jan 22;26:e919566-1–e919566-9. doi: 10.12659/MSM.919566

Figure 2.

Figure 2

Trop2 dysregulation affected GC cell proliferation inhibition induced by drugs. (A) The IC50 value of DDP in BGC823-shTrop2 cells was 0.355±0.033 μg/ml, lower than that of BGC823-NC (0.701±0.083μg/ml) (P=0.002). (B) BGC823-shTrop2 treated with 5-FU showed a lower IC50 value(0.338±0.253μg/ml) than that of BGC823-NC (1.101±0.470/ml) (P=0.011). (C) The IC50 value of DDP in HGC27-ovTrop2 cells was 2.102±0.274μg/ml, higher than that of HGC27-NC cells (0.749±0.163μg/ml) (P=0.002). (D) HGC27-ovTrop2 cells treated with 5-FU showed a higher IC50 value (0.172±0.038μg/ml) than that of HGC27-NC cells (0.069±0.007/ml) (P=0.01).