Table 1. Bisphosphonates (zoledronic acid) and denosumab in patients with bone metastases: current demonstrated efficacy in different cancer types.

Zoledronic acid	Multiple myeloma [48, 49]
	Breast cancer [48, 49, 50]
	Lung cancer [64]
	Renal cell carcinoma [53]
	Prostate cancer [49]
Denosumab	Multiple myeloma [58]
	Breast cancer [59, 60]
	Prostate cancer [59, 60, 62, 63]
	Hepatocellular carcinoma [55]
	Ewing Sarcoma [65]