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. 2020 Jan 28;11(4):362–377. doi: 10.18632/oncotarget.27406

Figure 3. The PMEPA1 isoforms (c, d and e) were categorized into two subgroups in prostate cancer cells: androgen responsive and TGF-β responsive.

Figure 3

The transcript levels of PMEPA1 isoforms (c, d and e) were assessed by Q-PCR in androgen responsive LNCaP cells and TGF-β responsive PC3 cells. (A) LNCaP cells treated with R1881 at linear dosages of 0, 0.1 and 1.0 nM for 24 hours. (B) PC3 cells treated with TGF-β at linear dosages of 0, 5 and 25 ng/ml for 24 hours. (C) LNCaP Cells were transfected with pCMV-XL5-wild-type AR, -T877A mutant AR and pCMV-XL5 as control. (D) LNCaP Cells were transfected with AR siRNA and scramble siRNA as control. (E) PC3 cells were transfected with pcDNA3.1-TGFRI and pcDNA3.1 as control. (F) PC3 cells were transfected with TGFRI siRNA and non-target siRNA as control.