Table 3.
The 7 CpGs significantly hypermethylated in all four datasets (FDR <0.05)
| Cross‐cohort hypermethylated CpGs (N = 7, FDR <0.05) | Illumina 450 K annotationa | ||||||
|---|---|---|---|---|---|---|---|
| CpG | MADTcoef b | LSADT2coef b | LSADT1coef b | LBC1921coef b | Gene (Name) | Gene (Group) | CpG Island |
| cg03055837 | 0.897143 (4) | 1.008964 (3) | 1.399633 (2) | 2.602283 (1) | NLGN4Y | TSS1500 | N_Shore |
| cg00311963 | 0.89143 (4) | 0.988388 (3) | 1.17261 (2) | 1.917789 (1) | LOC100101121;TTTY23 | TSS1500 | S_Shore |
| cg00679624 | 0.836824 (4) | 1.03516 (3) | 1.069887 (2) | 2.545285 (1) | Island | ||
| cg14180491 | 1.133525 (4) | 2.143094 (2) | 2.780263 (1) | 2.068691 (3) | DDX3Y | 5'UTR;1stExon | Island |
| cg01707559 | 1.194551 (4) | 1.733023 (2) | 1.228877 (3) | 4.47433 (1) | TBL1Y | TSS200 | Island |
| cg18188392 | 1.989856 (4) | 2.556912 (3) | 2.715966 (2) | 3.89269 (1) | Island | ||
| cg06636270 | 1.017389 (4) | 2.124417 (2) | 1.581355 (3) | 2.837249 (1) | TTTY20 | TSS1500 | N_Shore |
a
UCSC annotation, University of California, Santa Cruz.
b
The coefficients are based on regression coefficients for age, and the number in parenthesis indicates order ranked from highest to lowest coefficient (1–4).