Figure 4.

PEX19 suppresses age‐dependent accumulation of mutations. (a) Schematic of the experiment to measure age‐dependent mutation frequency. See main text for details. (b) CAN1 forward mutation rate in young wt and pex19∆ cells. Values from three independent experiments are plotted. The thick dark bars represent the median values. ns: nonsignificant. (c) Age‐dependent mutation frequencies at the CAN1 locus in wt (replicative age ~17) and pex19∆ (replicative age ~15.5) cells. The difference between observed and expected mutation frequencies from four independent experiments is plotted. The horizontal bars represent the median values. p‐value was determined by Student's t test