Fig 4. Tissue and nerve injury-induced mechanical hypersensitivity in Hippocalcin-like 4 mutant mice.

(A-B) Mechanical allodynia did not differ between Hpcal4 mutant and control mice 3 days after CFA injection. (C-D) Hpcal4 mutant mice also developed normal mechanical allodynia 2 and 7 days after spared nerve injury (SNI). Data are presented as mean ± SEM. Statistical significance was determined by Student’s t-test in A and B and by Two-way repeated measures ANOVA in C and D.