Fig. 1.

Comparison of fibrin clot parameters in plasma samples from individuals with T1DM and controls. ( A, B ) Fibrin clot parameters were compared between controls and T1DM, ( C, D ) between all males and females with T1DM and ( E ) between males and females under 30 years old with T1DM. Clot formation experiments were performed in plasma ( n  = 47 for subjects with T1DM and n  = 45 for controls). Plasma was diluted six-fold in buffer and the final concentrations of reagents used were: 7.5 mM CaCl ₂ , 0.03 U/mL thrombin, and 20.8 ng/mL tPA. ( A, C ) Maximum absorbance and (B, D, E) and lysis time were measured. Maximum absorbance was not different between the control and the T1DM groups. Lysis time was increased in individuals with T1DM compared with controls ( p  = 0.0273). Maximum absorbance and lysis time were not different when comparing all males and females with T1DM or only those under 30 years old. Statistical significance is indicated with ns where p  > 0.05 and *** where p  < 0.001.