Table 1: Patient characteristics, Surgery and Response Outcome.
Data are presented as n (%) or median (range). Abbreviations: APR = Abdominoperineal Resection; W&W = Watch and Wait; TEM = Transanal Endoscopic Microsurgery; pCR = pathologic Complete Response.
| Development cohort (n = 70) | Validation cohort (n = 55) | ||
|---|---|---|---|
| Age (years) | 64 (56–69) | 64 (56–70) | |
| Sex | |||
| Female | 23 (33%) | 13 (24%) | |
| Male | 47 (67%) | 42 (76%) | |
| Clinical tumor stage | |||
| T2 | 12 (17%) | 0 (0%) | |
| T3 | 55 (79%) | 46 (84%) | |
| T4 | 3 (4%) | 9 (16%) | |
| Clinical nodal stage | |||
| N0 | 3 (4%) | 5 (9%) | |
| N1 | 19 (27%) | 15 (27%) | |
| N2 | 48 (69%) | 35 (64%) | |
| Interval to Surgery (days) | 54 (49–56) | 55 (48–60) | |
| Type of surgery | |||
| Sphincter-sparing | 64 (91%) | 36 (65%) | |
| APR | 4 (6%) | 18 (33%) | |
| W&W | 2 (3%) | 0 (0%) | |
| TEM | 0 (0%) | 1 (2%) | |
| pCR (ypT0N0) | |||
| No | 58 (83%) | 47 (85%) | |
| Yes | 12 (17%) | 8 (15%) | |
| Near-pCR (ypT0–1N0) | |||
| No | 49 (70%) | 42 (76%) | |
| Yes | 21 (30%) | 13 (24%) | |