Figure 4.

(A) Thirteen WGCNA modules identified from transcriptome-wide peripheral blood gene expression data were found to be differentially expressed in cases with major psychosis (bipolar disorder + schizophrenia) relative to unaffected comparison subjects. (B) The top three most significantly over-represented Gene Ontology (GO) gene sets found in the 13 major psychosis-associated WGCNA modules. (C) A heat map showing the degree of similarity between pairs of modules based on the similarity of the sets of GO gene sets that were over-represented in the 13 major psychosis-associated modules. Similarity index is on a 0 – 1 scale, with a value closer to 1.0 indicating high similarity. Rows and columns in the heat map were ordered by performing hierarchical clustering on the pair-wise similarity values.