Figure 4.

Proliferative capacity and cell cycle distribution in gemcitabine (GEM)‐resistant and parental cell lines. A and B, CCK8 assays showed inhibited proliferation in GEM‐resistant cells (BxPC‐3‐GR and CFPAC1‐GR) compared with their corresponding parental cells. C, Representative images of cell cycle distribution analysis in BxPC‐3 and BxPC‐3‐GR cells. D, Quantification of cell cycle distribution analysis revealed that BxPC‐3‐GR cells were arrested in the G1 phase. E, Representative images of cell cycle distribution analysis in CFPAC‐1 and CFPAC‐1‐GR cells. F, Quantification of cell cycle distribution analysis revealed that CFPAC‐1‐GR cells were arrested in the G1 phase. **P < .01, ***P < .001; comparisons indicated by lines. NS, no significant difference