Table 1.
Characteristics of patients with TNBC from the SEER database by metastasis patterns
| Variables |
Control group N = 21 726(%) |
Distant metastasis group | |||
|---|---|---|---|---|---|
|
Bone N = 559(%) |
Brain N = 124 (%) |
Liver N = 369 (%) |
Lung N = 492 (%) |
||
| Survival (months) | 26.66 ± 17.09 | 10.94 ± 11.30 | 7.68 ± 7.642 | 9.70 ± 9.93 | 11.19 ± 10.60 |
| Age at diagnosis, y | P = .010 | P = .231 | P = .440 | P < .001 | |
| ＜50 | 6557 (30.18) | 141 (25.25) | 32 (25.53) | 105 (28.35) | 113 (23.14) |
| ≥50 | 15 169 (69.82) | 418 (74.75) | 92 (74.47) | 264 (71.65) | 378 (76.86) |
| Race | P < .001 | P = .580 | P = .079 | P < .001 | |
| White | 15 573 (71.68) | 381 (68.14) | 91 (73.05) | 255 (69.02) | 321 (65.29) |
| Black | 4465 (20.55) | 149 (26.61) | 27 (21.99) | 92 (24.93) | 132 (26.86) |
| Othera | 1560 (7.18) | 29 (5.25) | 6 (4.96) | 22 (6.04) | 39 (7.84) |
| Unknown | 128 (0.59) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) |
| Marital status | P < .001 | P < .001 | P < .001 | P < .001 | |
| Unmarriedb | 8634 (39.74) | 294 (52.54) | 69 (55.32) | 193 (52.23) | 280 (56.86) |
| Married | 11 941 (54.96) | 242 (43.22) | 51 (41.13) | 156 (42.26) | 185 (37.65) |
| Unknown | 1151 (5.30) | 24 (4.24) | 4 (3.55) | 20 (5.51) | 27 (5.49) |
| Grade | P < .001 | P < .001 | P < .001 | P < .001 | |
| Well | 354 (1.63) | 10 (1.86) | 2 (1.42) | 2 (0.52) | 6 (1.18) |
| Moderately | 3498 (16.10) | 99 (17.63) | 21 (17.02) | 61 (16.54) | 58 (11.76) |
| Poorly | 16 938 (77.96) | 375 (67.12) | 77 (62.41) | 262 (71.13) | 368 (74.71) |
| Undifferentiated | 154 (0.71) | 9 (1.53) | 4 (2.84) | 5 (1.31) | 6 (1.18) |
| Unknown | 782 (3.60) | 66 (11.86) | 20 (16.31) | 39 (10.50) | 55 (11.18) |
| Laterality | P < .001 | P < .001 | P < .001 | P < .001 | |
| Left | 11 115 (51.16) | 281 (50.34) | 63 (51.06) | 189 (51.18) | 246 (50.00) |
| Right | 10 607 (48.82) | 271 (48.47) | 59 (47.52) | 177 (48.03) | 244 (49.61) |
| Bilateral | 4 (0.02) | 7 (1.19) | 2 (1.42) | 3 (0.79) | 2 (0.39) |
| Histology | P < .001 | P < .001 | P < .001 | P < .001 | |
| IDC | 19 311 (88.89) | 467 (83.54) | 103 (83.06) | 330 (89.43) | 427 (86.79) |
| MBC | 664 (3.05) | 10 (1.78) | 5 (4.03) | 3 (0.81) | 26 (5.28) |
| MedBC | 301 (1.39) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.41) |
| IDC‐ILC | 270 (1.24) | 19 (3.40) | 4 (3.23) | 9 (2.44) | 4 (0.81) |
| ILC | 230 (1.06) | 31 (5.55) | 3 (2.42) | 10 (2.71) | 4 (0.81) |
| IDC‐oth | 630 (2.90) | 9 (1.61) | 3 (2.42) | 5 (1.36) | 10 (2.03) |
| AAC | 208 (0.96) | 2 (0.36) | 0 (0.00) | 1 (0.27) | 0 (0.00) |
| IBC | 112 (0.51) | 21(3.76) | 6 (4.84) | 11 (2.98) | 19 (3.86) |
| Tumor size(mm) | P < .001 | P < .001 | P < .001 | P < .001 | |
| ≤50 | 19 226 (88.49) | 289 (51.70) | 62 (50.00) | 180 (48.78) | 195 (39.63) |
| ＞50 | 2353 (10.83) | 214 (38.28) | 49 (39.51) | 162 (43.90) | 261 (53.05) |
| Unknown | 147 (0.68) | 56 (10.02) | 13 (10.48) | 27 (7.32) | 36 (7.32) |
| Node stage | P < .001 | P < .001 | P < .001 | P < .001 | |
| Negative | 14 165 (65.20) | 116 (20.68) | 22 (17.73) | 72 (19.42) | 101 (20.59) |
| Positive | 7561 (34.80) | 443 (79.32) | 102 (82.27) | 297 (80.58) | 391 (79.41) |
| Radiotherapy | P < .001 | P < .001 | P < .001 | P < .001 | |
| Yes | 10 878 (50.07) | 227 (40.68) | 90 (72.34) | 96 (25.98) | 159 (32.35) |
| No/Unknown | 10 847 (49.93) | 332 (59.32) | 34 (27.66) | 273 (74.02) | 333 (67.65) |
| Chemotherapy | P = .691 | P = .872 | P = .842 | P = .016 | |
| Yes | 16 614 (76.47) | 423 (75.76) | 94 (75.89) | 284 (76.90) | 351 (71.43) |
| No/Unknown | 5112 (23.53) | 136 (24.24) | 30 (24.11) | 85 (23.10) | 141 (28.57) |
Bold indicates statistically significant value.
a
Including American Indian/Alaskan native, Asian/Pacific Islander, and others—unspecified.
b
Including divorced, separated, single (never married), unmarried, domestic partner, and widowed.