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. 2019 Dec 9;9(3):872–881. doi: 10.1002/cam4.2759

Table 2.

Univariate analysis of predictive factors of preferential DMS

  Bone metastasis Brain metastasis Liver metastasis Lung metastasis
OR (95% CI) P value OR (95% CI) P value OR (95% CI) P value OR (95% CI) P value
Age at diagnosis, y
<50 REFa REF REF REF REF REF REF REF
≧50 1.000 (0.761‐1.315) .998 0.983 (0.655‐1.475) .934 0.864(0.660‐1.131) .288 1.294(1.000‐1.676) .050
Race
White REF REF REF REF REF REF REF REF
Black 0.991 (0.754‐1.302) .949 0.740 (0.483‐1.133) .166 0.883 (0.662‐1.177) .395 1.093 (0.833‐1.436) .521
Otherb 0.733 (0.456‐1.179) .201 0.673 (0.300‐1.510) .337 0.864 (0.514‐1.452) .580 1.648 (1.041‐2.608) .033
Marital Status
Unmarriedc REF REF REF REF REF REF REF REF
Married 1.119 (0.853‐1.467) .418 0.852 (0.559‐1.3) .458 0.782 (0.439‐1.391) .402 0.742 (0.580‐0.949) .018
Unknown 0.864 (0.48‐1.554) .625 0.692 (0.236‐2.033) .504 0.829 (0.463‐1.485) .528 1.147 (0.653‐2.014) .633
Primary Tumor Site
Upper‐inner REF REF REF REF REF REF REF REF
Upper‐outer 0.872 (0.518‐1.469) .607 0.725 (0.341‐1.541) .403 0.946 (0.551‐1.624) .840 1.154 (0.681‐1.956) .595
Lower‐inner 1.088 (0.502‐2.358) .831 0.621 (0.182‐2.123) .448 0.880 (0.392‐1.974) .756 1.331 (0.614‐2.884) .468
Lower‐outer 0.659 (0.313‐1.389) .273 0.549 (0.161‐1.867) .337 0.908 (0.417‐1.977) .809 1.664 (0.788‐3.515) .182
Central portion 0.946 (0.463‐1.934) .880 0.347 (0.091‐1.330) .123 1.210 (0.582‐2.516) .610 1.086 (0.528‐2.237) .822
Axillary tail 4.079 (0.452‐36.769) .210 —d — 0.880 (0.150‐5.151) .887 0.732 (0.125‐4.273) .732
Otherse 0.997 (0.603‐1.650) .992 1.066 (0.524‐2.167) .860 0.909 (0.540‐1.532) .721 1.376 (0.827‐2.289) .219
Grade
Well REF REF REF REF REF REF REF REF
Moderately 0.473 (0.127‐1.762) .264 1.029 (0.217‐4.887) .972 3.743 (0.811‐17.278) .091 0.769 (0.255‐2.323) .642
Poorly 0.286 (0.079‐1.032) .056 0.770 (0.169‐3.496) .735 3.233 (0.718‐14.549) .126 1.293 (0.444‐3.760) .638
Undifferentiated 0.351 (0.070‐1.761) .203 2.000 (0.306‐13.062) .469 2.727 (0.436‐17.046) .283 0.800 (0.185‐3.460) .765
Unknown 0.324 (0.086‐1.215) .095 1.302 (0.273‐6.216) .741 2.697 (0.577‐12.613) .208 1.056 (0.346‐3.216) .924
Laterality
Left REF REF REF REF REF REF REF REF
Right 1.072 (0.844‐1.360) .569 0.998 (0.699‐1.425) .989 1.010 (0.787‐1.296) .939 1.123 (0.885‐1.426) .339
Bilateral 3.135 (0.646‐15.221) .156 1.948 (0.397‐9.562) .411 0.944 (0.233‐3.814) .935 0.345 (0.071‐1.676) .187
Histology Type                
IDC REF REF REF REF REF REF REF REF
MBC 0.414 (0.194‐0.884) .023 1.419 (0.534‐3.765) .483 0.176 (0.053‐0.583) .004 4.719 (1.924‐11.576) .001
MedBC — — — — — — — —
IDC‐ILC 2.470 (1.028‐5.934) .043 1.393 (0.471‐4.122) .550 0.902 (0.397‐2.046) .804 0.198 (0.068‐0.579) .003
ILC 4.702 (1.943‐11.381) .001 0.676 (0.204‐2.240) .522 0.631 (0.301‐1.320) .523 0.132 (0.046‐0.376) .001
IDC‐oth 1.024 (0.391‐2.678) .962 1.641 (0.464‐5.809) .442 0.710 (0.248‐2.032) .523 1.556 (0.587‐4.123) .374
AAC — — — — 1.703 (0.106‐27.318) 0.707 — —
IBC 1.194 (0.615‐2.319) .600 1.483 (0.604‐3.639) .390 0.721 (0.351‐1.477) .721 1.149 (0.595‐2.219) .678
Tumor size
≦5 cm REF REF REF REF REF REF REF REF
>5 cm 0.833 (0.660‐1.051) .123 0.957 (0.645‐1.418) .825 1.135 (0.882‐1.460) .326 1.226 (0.753‐1.826) .463
Unknown 1.182 (0.795‐1.759) .408 1.207 (0.640‐2.274) .561 0.799 (0.503‐1.272) .345 1.061 (0.691‐1.628) .787
Lymph nodes
Negative REF REF REF REF REF REF REF REF
Positive 1.063 (0.795‐1.421) .681 1.282 (0.811‐2.029) .288 1.175 (0.862‐1.600) .307 1.065 (0.796‐1.425) .672
Radiotherapy
No/Unknown REF REF REF REF REF REF REF REF
Yes 1.948 (1.506‐2.520) .001 6.645 (4.477‐9.863) .001 0.570 (0.433‐0.749) .001 0.878 (0.683‐1.129) .310
Chemotherapy
No/Unknown REF REF REF REF REF REF REF REF
Yes 0.938 (0.709‐1.240) .652 0.974 (0.644‐1.474) .902 1.053 (0.785‐1.412) .732 1.018 (0.770‐1.346) .901

Bold indicates statistically significant value.

a

For calculation of OR value, a group of patients were defined as reference.

b

Including American Indian/Alaskan native, Asian/Pacific Islander, and others—unspecified.

c

Including divorced, separated, single (never married), unmarried, domestic partner, and widowed.

d

The number of patients was not enough for further calculation.

e

Including nipple and overlapping carcinoma