Table 4. Functional pathways enriched by 54 genes contributing to both NAFLD and HbA1c levels.
| Name | Overlap genes | Jaccard similarity | P-value after FDR | P-value before FDR |
|---|---|---|---|---|
| Response to nutrient levels | 24 | 0.040268 | 2.07E-20 | 1.55E-24 |
| Response to extracellular stimulus | 24 | 0.038339 | 5.3E-20 | 5.28E-24 |
| Response to hormone | 26 | 0.0282 | 9.73E-19 | 1.46E-22 |
| Insulin -> STAT Expression Targets | 20 | 0.103627 | 1.96E-17 | 6.84E-21 |
| Response to peptide hormone | 19 | 0.04034 | 3.68E-16 | 1.84E-19 |
| Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets | 19 | 0.093137 | 1.43E-15 | 8.19E-19 |
| Response to peptide | 19 | 0.036538 | 2.25E-15 | 1.35E-18 |
| Aging | 18 | 0.040359 | 2.78E-15 | 1.74E-18 |
| Insulin -> MEF/MYOD Expression Targets | 19 | 0.090047 | 2.78E-15 | 1.8E-18 |
| Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets | 19 | 0.086364 | 6.77E-15 | 4.73E-18 |