Table 3.
Hematological and blood chemical parameters for mice after different chronic doses of FA@Fe3O4 NPs.
| Parameters | Control | 10 (mg kg−1) | 25 (mg kg−1) | 50 (mg kg−1) | 100 (mg kg−1) |
|---|---|---|---|---|---|
| WBC (1000/mm3) | 6.5 ± 2.7 | 7.2 ± 3.1 | 5.6 ± 3.9 | 6.2 ± 0.7 | 7.1 ± 3.9 |
| % Lymph | 63 ± 14 | 60 ± 16 | 70.5 ± 9.1 | 67 ± 10.4 | 63.3 ± 22 |
| RBC (Millin/mm3) | 7.1 ± 1.4 | 6.9 ± 1 | 7.2 ± 1 | 6.7 ± 1.5 | 7.1 ± 1.6 |
| Hgb (g/dL) | 11.6 ± 1.9 | 11.1 ± 1 | 11.5 ± 1 | 10.2 ± 2.2 | 10.9 ± 2.1 |
| HCT (%) | 35.6 ± 5.2 | 33 ± 2.8 | 36.6 ± 3.2 | 31.9 ± 7.4 | 33.8 ± 8.3 |
| MCV (FL) | 49.8 ± 5.9 | 50.5 ± 5.6 | 51.2 ± 5.8 | 50 ± 4.7 | 49.1 ± 2.1 |
| MCH (pg) | 15.6 ± 2.5 | 15.9 ± 1.9 | 16.1 ± 2.3 | 15.9 ± 2.6 | 15.5 ± 2.9 |
| MCHC (mol/L) | 30.4 ± 1.7 | 31.6 ± 0.6 | 31.4 ± 0.9 | 31.8 ± 3 | 31.3 ± 2.3 |
| PLT (1000/mm3) | 1066 ± 462 | 953 ± 199 | 1226 ± 232 | 986 ± 252 | 1155 ± 591 |
| BUN (mg/dL) | 24 ± 6 | 25.5 ± 7 | 27 ± 10 | 28 ± 10 | 29.6 ± 4 |
| ALP (U/L) | 203 ± 38 | 209 ± 39 | 202 ± 41 | 166 ± 58 | 111 ± 36* |
| AST (U/L) | 95.5 ± 21 | 109 ± 36 | 108 ± 47 | 110 ± 48 | 98 ± 46 |
| ALT (U/L) | 21 ± 5 | 24 ± 4 | 20 ± 10 | 22 ± 4 | 21.5 ± 1 |
| GLU (mg/dL) | 74 ± 10 | 65 ± 41 | 84.5 ± 18 | 85 ± 14 | 67 ± 19 |
| Ca (mM/L) | 3.5 ± 0.9 | 3.7 ± 0.3 | 3.7 ± 0.5 | 3.8 ± 0.9 | 4.2 ± 1 |
| Mg (mM/L) | 0.95 ± 0.1 | 1.2 ± 0.2 | 1.1 ± 0.3 | 1.2 ± 0.6 | 1.1 ± 0.5 |
| D.Bil (mg/dL) | 0.04 ± 0.03 | 0.06 ± 0.02 | 0.07 ± 0.04 | 0.04 ± 0.02 | 0.06 ± 0.02 |
| TP (mg/dL) | 1.4 ± 0.1 | 1.4 ± 0.2 | 1.3 ± 0.1 | 1.1 ± 0.3 | 1.5 ± 0.04 |
Values are means ± SD, and (*) indicates P < 0.05 compared to the control group. RBC = red blood cell, HCT = hematocrit, Hbg = hemoglobin, WBC = white blood cells, Plt = platelets, BUN = blood urea nitrogen, Cr = creatinine, Glu = glucose, AST = aspartate transaminase, ALT = alanine transaminase, ALP = alkaline phosphatase, Alb = albumin, T.P = total protein, B.T = Bilirubin Total, D.Bil = Direct Bilirubin. MCV = mean corpuscular volume, MCH = mean corpuscular hemoglobin, MCHC = mean corpuscular hemoglobin concentration, Ca = calcium, and Mg = magnesium.