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. 2020 Feb 3;10:1688. doi: 10.1038/s41598-020-58655-7

Figure 5.

Figure 5

miR-1010 controls synaptic homeostasis by downregulating nAcRβ2 (A) nAcRβ2 is part of incoherent feedforward loop to temper synaptic potentials and a negative feedback loop through which miR-1010 downregulates nAcRβ2 upon receptor activation. (B) Both loops work cooperatively to prevent synaptic potentials from overshooting their optimal range. (C) Long-term average potential response obtained by mass-action kinetic simulation of model outlined in (A). Resting potential defined to 0 (corresponding to ~−70meV). Curves normalised to maximum potential in wild-type simulation (parameters and description in Supplementary Note). Time is scaled relative to the lifetime of nAcRβ2. Δt represents delay in potential in miR-1010+/− and SKIP−/− to return to less than 20% of peak response in wild-type conditions.