Table 1.

Conditions associated with inflammasome activation in the field of Reproductive Biology.

Condition	Findings	References
Female infertility	NLRP3 gene polymorphism associated with female infertility	(19)
Male infertility	Inflammasome inhibition improves sperm motility in spinal cord injured men	(16, 17)
Endometriosis	Inflammasome signaling proteins are elevated in the endometrium of females with recurrent pregnancy loss	(28)
Preeclampsia	The NLRP3 inflammasome contributes to the inflammatory response seen in preeclampsia	(25, 29, 30)
Preterm births	Caspase-1, ASC, and IL-1β genes are elevated in preterm birth mice	(26)
Reproductive senescence	Inflammasome proteins are carried in EV released by female reproductive organs that reach the brain, contributing to brain inflammation	(27)