Table 4.

Multivariate Analysis of Change in NLR for Patient Outcomes

Variables	Progression-Free Survival		Overall Survival
HR (95% CI)	p value	HR (95% CI)	p value
Presence of hepatitis	5.08 (1.43–12.98)	0.012	3.79 (1.14–10.38)	0.114
Tumor size (≥1.5cm)	1.02 (0.35–3.55)	0.820	1.01 (0.12–3.93)	0.784
Pre-treatment RBC count (≥4.5x1012/L)	0.25 (0.07–0.88)	0.031	0.11 (0.02–0.64)	0.014
Pre-treatment AFP (≥20.0 ng/mL)	2.05 (0.67–6.23)	0.208	4.12 (0.77–10.07)	0.098
Change in NLR (≥2.7-fold)	1.54 (0.61–3.87)	0.360	3.43 (1.14–10.38)	0.029

Abbreviations: NLR, neutrophil-to-lymphocyte ratio; RBC, red blood cell; AFP, alpha-fetoprotein; HR, hazard ratio; CI, confidence interval.