Table 3.
The Examples of NMOFs in Combination Cancer Therapy
| Therapy Strategies | NMOFs | Cancer Cell Types | Animal Models | References | |
|---|---|---|---|---|---|
| Dual Chemo-drugs | 5-Fu/DOX | 5-FU@ZIF-90-DOX | None | None | [69] |
| Chemo/siRNAs | Cisplatin/siRNAs | siRNA/UiO-Cis | SKOV-3 cells | None | [68] |
| Paclitaxel/siRNAs | Se/Ru@MIL-101-(P+V)siRNA | MCF-7/T cells | Mice bearing MCF-7/T tumors | [77] | |
| Chemo/PDT | DOX/PDT | DOX@NPMOFs | HepG2 cells | Mice bearing HepG2 tumors | [32] |
| DOX/PDT | DOX/UCMOFs | 4T1 cells | Mice bearing 4T1 tumors | [93] | |
| DOX/PDT | NH2-MIL-125/PEG | MCF-7 cells | None | [94] | |
| Tirapazamine/PDT | TPZ/Hf/TCPP/PEG | 4T1 cells | Mice bearing 4T1 tumors | [27] | |
| Banoxantrone/PDT | A@UiO‐66‐H‐P | U87MG cells | Mice bearing U87MG tumors | [95] | |
| Chemo/PTT | DOX/PTT | Au@Cu3(BTC)2NPs | A549 cells | Mice bearing A549 tumors | [96] |
| Chemo/PTT/PDT | CPT/PTT/PDT | AuNR@MOFs@CPT | 4T1 cells | Mice bearing 4T1 tumors | [97] |
| PTT/NO | NMOF–SNO | MCF-7 cells | Mice bearing MCF-7/T tumors | [25] | |
| PDT/RT | Hf-TCPP NMOF-PEG | 4T1 cells | Mice bearing 4T1 tumors | [66] | |
| PDT/Immunotherapy | PDT/IDOi | IDOi@TBC-Hf | CT26/MC38 cells | Mice bearing CT26/MC38 tumors | [88] |
| PDT/αPD-1 | TBP-nMOF | 4T1 cells | Mice bearing 4T1 tumors | [89] | |
| PDT/αPD-L1 | Fe-TBP | CT26 cells | Mice bearing CT26 tumors | [87] | |
| RT/Immunotherapy | RT/αPD-L1 | Hf6-DBA and Hf12-DBA | CT26 cells | Mice bearing CT26 tumors | [91] |
Abbreviations: RT-RDT, radiotherapy-radiodynamic therapy; PDT, photodynamic therapy; PTT, photothermal therapy; IDOi, Indoleamine 2.3-dioxygenase inhibitor; αPD-1, anti-programmed death-1; α-PD-L1, anti-programmed death-ligand 1; 5-FU, 5-fluorouracil; DOX, doxorubicin; NP,nanoparticles; PEG, polyethylene glycol; TPZ, tirapazamine; TCPP, tetra(4-carboxyphenyl)porphine; BTC, 1,3,5-benzenetricarboxylate; CPT, camptothecin; SNO, S-Nitrosothiol; TCPP, tetra(4-carboxyphenyl)porphine; TBC, tetra(p-benzoato)chlorin; TBP, 5,10,15,20-tetra(p-benzoato)porphyrin; DBA, 2.5-di(p-benzoato)aniline.