Table 1.
Correlation between Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and clinical measures.
| KEGG ID | pBH | Odds ratio | Term |
|---|---|---|---|
| POSITIVE CORRELATION WITH BBS | |||
| 565 | 0.0170 | 10.31 | Ether lipid metabolism |
| 4330 | 0.0179 | 7.72 | Notch signaling pathway |
| 3008 | 0.0429 | 4.38 | Ribosome biogenesis in eukaryotes |
| NEGATIVE CORRELATION WITH BBS | |||
| 4660 | 0.0000 | 8.77 | T cell receptor signaling pathway |
| 5340 | 0.0000 | 15.28 | Primary immunodeficiency |
| 4640 | 0.0002 | 5.87 | Hematopoietic cell lineage |
| 5142 | 0.0112 | 3.64 | Chagas disease (American trypanosomiasis) |
| 5200 | 0.0112 | 2.32 | Pathways in cancer |
| 5322 | 0.0112 | 3.17 | Systemic lupus erythematosus |
| 4514 | 0.0247 | 2.79 | Cell adhesion molecules (CAMs) |
| 5020 | 0.0383 | 4.62 | Prion diseases |
| 5330 | 0.0383 | 4.35 | Allograft rejection |
| POSITIVE CORRELATION WITH LENGTH | |||
| 4380 | 0.0021 | 3.53 | Osteoclast differentiation |
| 4662 | 0.0038 | 4.20 | B-cell receptor signaling pathway |
| 4910 | 0.0045 | 3.00 | Insulin signaling pathway |
| 5212 | 0.0045 | 4.05 | Pancreatic cancer |
| 4210 | 0.0053 | 3.53 | Apoptosis |
| 4370 | 0.0053 | 3.68 | VEGF signaling pathway |
| 4664 | 0.0053 | 3.52 | Fc epsilon RI signaling pathway |
| 4660 | 0.0053 | 3.05 | T-cell receptor signaling pathway |
| 5223 | 0.0053 | 4.20 | Non-small cell lung cancer |
| 4666 | 0.0053 | 3.22 | Fc gamma R-mediated phagocytosis |
| 5120 | 0.0055 | 3.69 | Epithelial cell signaling in Helicobacter pylori infection |
| 4722 | 0.0059 | 2.78 | Neurotrophin signaling pathway |
| 4620 | 0.0080 | 2.94 | Toll-like receptor signaling pathway |
| 5131 | 0.0081 | 3.64 | Shigellosis |
| 5142 | 0.0081 | 2.87 | Chagas disease (American trypanosomiasis) |
| 5214 | 0.0108 | 3.39 | Glioma |
| 5145 | 0.0161 | 2.43 | Toxoplasmosis |
| 4012 | 0.0166 | 2.79 | ErbB signaling pathway |
| 4650 | 0.0166 | 2.35 | Natural killer cell mediated cytotoxicity |
| 5220 | 0.0166 | 2.97 | Chronic myeloid leukemia |
| 4520 | 0.0166 | 2.97 | Adherens junction |
| 4330 | 0.0196 | 3.51 | Notch signaling pathway |
| 4150 | 0.0297 | 3.13 | mTOR signaling pathway |
| 4310 | 0.0297 | 2.10 | Wnt signaling pathway |
| 5160 | 0.0307 | 2.16 | Hepatitis C |
| 4720 | 0.0324 | 2.67 | Long-term potentiation |
| 5211 | 0.0324 | 2.67 | Renal cell carcinoma |
| 5140 | 0.0347 | 2.58 | Leishmaniasis |
| 4810 | 0.0347 | 1.84 | Regulation of actin cytoskeleton |
| 5221 | 0.0347 | 2.82 | Acute myeloid leukemia |
| 450 | 0.0364 | 5.10 | Selenocompound metabolism |
| 4360 | 0.0438 | 2.02 | Axon guidance |
| 4062 | 0.0478 | 1.78 | Chemokine signaling pathway |
| 4930 | 0.0478 | 2.78 | Type II diabetes mellitus |
| 520 | 0.0478 | 2.78 | Amino sugar and nucleotide sugar metabolism |
| 4670 | 0.0478 | 2.02 | Leukocyte transendothelial migration |
| 4140 | 0.0478 | 3.18 | Regulation of autophagy |
| 10 | 0.0478 | 2.43 | Glycolysis/gluconeogenesis |
| NEGATIVE CORRELATION WITH LENGTH | |||
| 4660 | 0.0000 | 4.08 | T-cell receptor signaling pathway |
| 5340 | 0.0000 | 8.02 | Primary immunodeficiency |
| 100 | 0.0010 | 9.15 | Steroid biosynthesis |
| 4710 | 0.0134 | 5.80 | Circadian rhythm—mammal |
| 4514 | 0.0156 | 2.35 | Cell adhesion molecules (CAMs) |
| 4640 | 0.0229 | 2.55 | Hematopoietic cell lineage |
| 4612 | 0.0229 | 2.66 | Antigen processing and presentation |
| 3020 | 0.0229 | 4.11 | RNA polymerase |
| 4650 | 0.0252 | 2.11 | Natural killer cell mediated cytotoxicity |
| 514 | 0.0351 | 2.96 | Other types of O-glycan biosynthesis |
| 5020 | 0.0358 | 3.28 | Prion diseases |
| 5215 | 0.0363 | 2.23 | Prostate cancer |
| 604 | 0.0392 | 4.90 | Glycosphingolipid biosynthesis—ganglio series |
| 3008 | 0.0436 | 2.19 | Ribosome biogenesis in eukaryotes |
| 5332 | 0.0480 | 2.73 | Graft-versus-host disease |
| POSITIVE CORRELATION WITH SPEED | |||
| 230 | 0.0332 | 4.22 | Purine metabolism |
| 1100 | 0.0480 | 1.95 | Metabolic pathways |
| NEGATIVE CORRELATION WITH SPEED | |||
| 5322 | 0.0000 | 11.30 | Systemic lupus erythematosus |
| 5020 | 0.0005 | 16.24 | Prion diseases |
| 5150 | 0.0019 | 9.83 | Staphylococcus aureus infection |
| 4610 | 0.0034 | 7.70 | Complement and coagulation cascades |
| 4514 | 0.0260 | 3.84 | Cell adhesion molecules (CAMs) |
| POSITIVE CORRELATION WITH UPDRS III | |||
| 534 | 0.0340 | 8.73 | Glycosaminoglycan biosynthesis—heparan sulfate |
| 3008 | 0.0340 | 4.53 | Ribosome biogenesis in eukaryotes |
| 340 | 0.0340 | 7.72 | Histidine metabolism |
| 3410 | 0.0364 | 6.69 | Base excision repair |
| 5200 | 0.0475 | 2.19 | Pathways in cancer |
| 310 | 0.0475 | 4.88 | Lysine degradation |
| 5222 | 0.0475 | 3.31 | Small cell lung cancer |
| 330 | 0.0480 | 3.92 | Arginine and proline metabolism |
| NEGATIVE CORRELATION WITH UPDRS III | |||
| 4621 | 0.0429 | 6.16 | NOD-like receptor signaling pathway |
| 4380 | 0.0429 | 3.67 | Osteoclast differentiation |
| 4664 | 0.0429 | 4.44 | Fc epsilon RI signaling pathway |
| 4080 | 0.0429 | 2.61 | Neuroactive ligand-receptor interaction |
| POSITIVE CORRELATION WITH TUG | |||
| 3040 | 0.0346 | 4.77 | Spliceosome |