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. 2020 Jan 28;9:1487. doi: 10.3389/fonc.2019.01487

Figure 5.

Figure 5

Effect of SSA on the expression of phospho-Akt, mTOR, MMP-2, and MMP-9 in TNBC cells and lung tissue of 4T1-luc mice. Western blot analysis of phospho-Akt, mTOR, MMP-2, and MMP-9 expression in SUM149 (A) and MDA-MB-231 (B) cells after treatment with SSA at the indicated concentrations for 24 h. Quantification of protein expression is shown below the Western blots. *p < 0.05; **p < 0.01; ***p < 0.001 compared with 0 μM of SSA. (C) Western blot analysis of phospho-Akt, mTOR, MMP-2, and MMP-9 expression in lung tissue of 4t1-luc mice after treatment with paclitaxel, AMD3100, and SSA for 2 weeks. Quantifications of C are shown below the Western blots. The independent experiments were performed in triplicate. *p < 0.05; **p < 0.01 compared with control group.