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. 2020 Jan 28;10:3059. doi: 10.3389/fimmu.2019.03059

Figure 1.

Figure 1

IL-27 signaling is not involved in nociceptive pain but protects the animals in neuropathic pain condition. Different behavior tests were realized in WT and IL-27−/− mice: mechanical nociceptive threshold using von Frey filaments (A) (n = 6). Percentage of withdrawal frequency using von Frey filaments (B) (n = 6). Thermal nociceptive threshold using hot plate test at different temperatures (C) (n = 6). Total duration (seconds) of nociceptive behavior for 0–10 min (first phase) and for 10 up to 50 min (second phase) after administration of formalin in the paw (D) (n = 6). Mechanical nociception test using percentage of withdrawal frequency (E) (n = 8) and acetone test (F) (n = 8), in which values represent withdrawal threshold before (day 0) and up to 21 days after nerve injury (SNI) or in sham-operated mice. Data are presented as means ± S.E.M. *P < 0.05, **P < 0.01, ***P < 0.001 vs. Sham-WT and #P < 0.05, ##P < 0.01, ###P < 0.001 vs. SNI-WT. Data were analyzed by t-test (A–D) and two-way ANOVA followed by Bonferroni post-test (E,F).