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. 2020 Jan 28;10:3059. doi: 10.3389/fimmu.2019.03059

Figure 5.

Figure 5

The impact of IL-27 deficiency in anti-inflammatory cytokine expression after peripheral nerve injury. WT and IL-27−/− mice were submitted to SNI or Sham surgeries, and at days 7, 10, and 14, tissues were collected to real-time PCR analysis: (A,B) Il10 expression relative to Gapdh in DRGs and in the spinal cord, respectively. (C,D) Level of IL-10 measured by ELISA in DRGs and in the spinal cord, respectively, on days 10 and 14 after SNI or Sham-operated (day 0) in WT and IL-27−/− mice. Data are presented as means ± S.E.M (n = 5–7). *P < 0.05 and **P < 0.01 vs. Sham-WT. #P < 0.05 and ##P < 0.01 vs. SNI-WT (A,B). *P < 0.05 and **P < 0.01 vs. Sham-operated (day 0). #P < 0.05 and ##P < 0.01 vs. SNI-WT (C,D). Data were analyzed by one-way ANOVA followed by Bonferroni post-test.