Table 2.
The common inducers and inhibitors of ferroptosis.
| Mechanisms | Drugs or compounds | |
|---|---|---|
| Inducer | Class1: Inhibit system Xc- and prevent cystine import | erastin, Sorafenib, Sulfasalazine |
| Class2: Inhibit GPX4 | RSL3, (1S,3R)-RSL3, DPI7, DPI10 | |
| Class3: Degrade GPX4, bind to SQS and deplete antioxidant CoQ10 | FIN56 | |
| Class4: Oxidize ferrous iron and lipidome directly, inactivate GPX4 indirectly | FINO2 | |
| Supplement: Target VDACs, degrade GPX4 | erastin | |
| Inhibitor | Class1: Inhibit accumulation of iron | DFO, Deferoxamine mesylate, 2,2’-pyridine |
| Class2: Inhibit lipid peroxidation | Fer-1, SRS11–9, SRS16–86, Liproxststatin-1, Vitamin E |
Ace acetaminophen, ART artesunate, COQ10 coenzyme Q10, DFO deferoxamine, Fer-1 Ferrostatin-1, GPX4 glutathione peroxidase 4, GSH glutathione; RSL3 Ras-selective lethal small molecule 3, VDACs voltage-dependent anion channels.