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. 2020 Feb 3;10:1725. doi: 10.1038/s41598-020-58361-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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4-(2-Aminoethyl) benzenesulfonyl fluoride hydrochloride (AEBSF) attenuated high-fat diet (HFD)-induced obesity and insulin resistance in male LDLR^−/− mice. (A) HFD-induced weight gain (n = 6–9/group). (B) Plasma concentrations of fasting glucose (B; n = 6−12/group) and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR; C; n = 6−9/group) in mice receiving HFD and HFD + AEBSF treatments. Plasma concentrations of glucose (D) and insulin (E) in an intraperitoneal glucose tolerance test for mice receiving the chow, HFD, and HFD + AEBSF treatments (n = 6/group). Total (F) and serine (G) protease activities in mice receiving the chow, HFD, and HFD + AEBSF treatments (n = 6/group) *P < 0.05, chow vs. HFD; ^♯p < 0.05, HFD vs. HFD + AEBSF. Values are means ± standard deviations.