Table 2.
Metabolic parameters at 10 weeks of dietary control in LDLR−/− mice.
| Chow (n = 7) |
HFD (n = 9) |
HFD + AEBSF (n = 9) |
|
|---|---|---|---|
| Glucose (mg/dl) | 105.4 ± 15.5 | 205.3 ± 24.2* | 155.5 ± 18.6#& |
| Cholesterol (mg/dl) | 255.7 ± 42.5 | 974.7 ± 95.2* | 519 ± 65.4#& |
| HDL-c (mg/dl) | 60.1 ± 11.1 | 285.8 ± 15.3* | 239.5 ± 40.8#& |
| LDL-c (mg/dl) | 91 ± 17.9 | 537.3 ± 43.3* | 429 ± 90.4#& |
| Triglycerides (mg/dl) | 109.3 ± 8.5 | 338.6 ± 48.2* | 230 ± 16.6#& |
| TNF-α (pg/ml) | 1.4 ± 0.22 | 3.2 ± 0.4* | 2.4 ± 0.2#& |
| IL-6 (pg/ml) | 5.8 ± 2.0 | 19.4 ± 6.2* | 14.8 ± 5.7#& |
| Leptin (μg/ml) | 0.94 ± 0.27 | 6.60 ± 2.41* | 2.71 ± 0.68#& |
| Adiponectin (μg/ml) | 38.12 ± 8.3 | 26.19 ± 4.82* | 36.3 ± 5.27# |
| Resistin (μg/ml) | 14.59 ± 4.4 | 25.56 ± 7.57* | 22.43 ± 8.16& |
| BUN (mg/dl) | 25 ± 1 | 34 ± 6.7* | 30.2 ± 3.5& |
| Creatinine (mg/dl) | 0.12 ± 0.01 | 0.2 ± 0.08* | 0.22 ± 0.06& |
| Total bilirubin (mg/dl) | 0.26 ± 0.07 | 0.12 ± 0.1* | 0.36 ± 0.1#& |
| ALP (u/l) | 68.2 ± 15 | 62.9 ± 15 | 83 ± 19.3# |
Values are means ± standard deviations. *p < 0.05, chow vs. HFD; #p < 0.05, HFD vs. HFD + AEBSF; &p < 0.05, Chow vs. HFD + AEBSF. HFD: high-fat diet; AEBSF: 4-(2-aminoethyl) benzenesulfonyl fluoride hydrochloride; TNF-α: tumor necrosis factor-alpha; IL-6: interleukin 6; BUN: blood urea nitrogen; ALP: alkaline phosphatase.