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. 2020 Feb 3;10:1653. doi: 10.1038/s41598-020-58569-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of heated and unheated spheroids at the same diameter. (A) Comparison of mean PI intensity in untreated (Control) and regrowing 80 CEM₄₃ treated HCT116-4000 and HCT116-300 spheroids (days 14–21) as a function of diameter. (B) Phase contrast and overlaid PI fluorescence images of comparably sized examples of an untreated and a heated HCT116-4000 spheroid demonstrating that heated samples had fewer necrotic, PI stained, cells at their core.