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. 2020 Feb 3;10:1699. doi: 10.1038/s41598-020-58562-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Collagen biosynthesis. (a) Col1A1 gene expression upon FFAs exposure vs. CTRL (dashed bar). (b) Col1A1 mRNA expression following treatment with FFAs and FXR agonists vs. FFAs (dashed bar). (c) Quantification of extracellular COL1A1 deposition upon FFAs exposure vs. CTRL (dashed bar). (d) Quantification of extracellular COL1A1 deposition following treatment with FFAs and FXR agonists vs. FFAs (dashed line). (e) Col1A1 gene expression upon FXR agonists treatment vs. CTRL (dashed line). (f) Quantification extracellular COL1A1 deposition upon FXR agonists treatment vs. CTRL (dashed line). Data is represented as mean ± SD of at least three independent biological replicates. *p < 0.05; **p < 0.01 vs. FFAs (b–d) or CTRL (A-C-E-F).