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. 2020 Feb 3;10:1699. doi: 10.1038/s41598-020-58562-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FXR pathway gene analysis. (a) FXR and SHP gene expression upon FFAs exposure vs. CTRL. (b) FXR gene expression upon FFAs and FXR agonists treatment vs. FFAs (dashed bar). (c) SHP gene expression upon FFAs and FXR agonists treatment vs. FFAs (dashed line). (d) FXR gene expression upon OCA and INT-767 treatment vs. CTRL (dashed line) (e) SHP gene expression upon OCA and INT-767 treatment vs. CTRL (dashed line). Data is represented as mean ± SD of at least three independent biological replicates. *p < 0.05; **p < 0.01 vs. FFAs (b,c) or CTRL (A-C-D).