Table 1.

Number of identified target genes showing only down-regulation, mixed regulation and up-regulation patterns among cancer tissues.

	Down-regulation	Mixed-regulation	Up-regulation
Concordant TFs	5	0	24
Discordant TFs	4	5	3

Differentially expressed target genes among all cancer tissues are divided on the base of the concordance of their targeting TFs methylation affinity and their TFBS methylation status. We define as “Concordant TFs” the TFs classified as MethylPlus and associated to a hyper-methylated motif or classified as MethylMinus and associated to a hypo-methylated motif in the corresponding cancer tissue. On the contrary, we define as “Discordant TFs” the TFs classified as MethylMinus and associated to a hyper-methylated motif or classified as MethylPlus and associated to a hypo-methylated motif in the corresponding cancer tissue.